I wonder if anyone has had any experience, or has any knowledge of Thrombocytopenia, often abbreviated to ITP, aborting R-Chop chemo.
It is common knowledge that many chemotherapy regimens can lower the platelet level such that the chemo cycles have to be delayed until the platelets rise back up to their normal state. However, there are very rare occasions where someone like me who has familial thrombocytopenia where chemo therapy just can’t be administered.
I have twice been given the poietin agonist drug Eltrombopag as a last resort ITP third line attempt to increase my platelets for surgery. The last time being for the surgery to remove the mass from my neck which diagnosed DLBCL. This not only raised my platelets for the operation but kept them above the required level for the first two R-Chop cycles. But, they then dropped back to my median level which is between 36 and 56 x 10 to the 9th/L
My consultant after a few weeks rest started me again on the drug in an attempt to get my platelets back up so as to be able to continue the chemo. Unfortunately, it would appear that I have become resistant to this drug and therefore with no where else to go the ITP is preventing any further chemo treatment.
I wonder if anyone has the knowledge of any second line treatment for DLBCL which is not dependant on high platelet levels or is compatible with ITP?